The SOX6 expression takes place during bone remodeling in the arthritis model.53Sox6 is the major factor for healing because it is able to enhance proliferation, inhibit apoptosis, and regulate osteogenesis-related gene expression.73The sox family, Sox5, Sox6, and Sox9, is involved in the activation and maintenance of chondrogenesis during fracture healing and the enhancement of chondrogenesis by BMP-274further Sox6 expression also determined bone mineral density.75 This evidence concerns the gene SOX6 and arthritic joint disease.