HIF1A and arthritic joint disease: The other protein that influences bone remodeling is Runt-related transcription factor 2 (Runx2).76This protein is essential for osteoblasts and osteoclasts differentiation.77Some research also mentions that upregulated Runx2 and Sox6 also contribute to bone formation, especially for chondrocyte differentiation.78Related to increased runx2 expression after supplementation of GSE on the arthritis model,53the supplementation also decreased the HIF-1α expression in the alveolar bone.