Axonotmesis on an infraorbital nerve induces an innate neuroinflammation response around the injured nerve tissue, defined as Wallerian degeneration (WD).11, 12, 13In peripheral nerve regeneration, BDNF can promote the viability and proliferation of neurons and SCs and induce axonal elongation via an autocrine and/or paracrine manner. This evidence concerns the gene BDNF and Wilson disease.