It was found that CHC1L expression was significantly reduced in prostate tumors compared to normal prostate tissues.16Low expression levels of CHC1L were also observed in peripheral blood lymphocytes of multiple myeloma patients when compared to those of healthy controls.17Recently, all cases of atypical pleomorphic lipomatous tumors showed consistent loss ofRB1and its flanking geneRCBTB2, where multiplex ligation-dependent probe amplification was used to evaluate genetic changes of 13q14.18Additionally, reduced expression ofCHC1Lhas also been observed in histiocyte-rich neoplasms.19 The gene discussed is RCBTB2; the disease is tumor of adipose tissue.