Of the 388 human genes identified via orthologous relationships to Drosophila genes mapped in our screen, 56 have previously been associated with AD in the NHGRI-EBI GWAS catalog, including 4 genes in well-established AD loci (ADAM10, ECHDC3, CELF1, SCARB2) (Kamboh 2022), and 20 more loci that have been identified in 2 or more studies (AFF1, AFGFG2, ASIC2, CELF2, DLG2, DLG4, FOXL1, FOXQ1, GALNT17, HIVEP3, HS3ST4, KNCIP1, KNCIP4, MUC2, RBFOX1, SCARB1, SDK1, SGIP1, SLC28A1, SPA17). The gene discussed is ECHDC3; the disease is Alzheimer disease.