While expression of Aβ has been reported to lead to age-dependent ommatidial degeneration in Drosophila models of AD, the expression of tau in the eye alone does not exhibit the same age-dependent changes, despite progressive age-related degeneration reported in other tissue types (Jackson et al. 2002; Finelli et al. 2004; Khurana 2008). The gene discussed is MAPT; the disease is Alzheimer disease.