Of the 388 human genes identified via orthologous relationships to Drosophila genes mapped in our screen, 56 have previously been associated with AD in the NHGRI-EBI GWAS catalog, including 4 genes in well-established AD loci (ADAM10, ECHDC3, CELF1, SCARB2) (Kamboh 2022), and 20 more loci that have been identified in 2 or more studies (AFF1, AFGFG2, ASIC2, CELF2, DLG2, DLG4, FOXL1, FOXQ1, GALNT17, HIVEP3, HS3ST4, KNCIP1, KNCIP4, MUC2, RBFOX1, SCARB1, SDK1, SGIP1, SLC28A1, SPA17). This evidence concerns the gene AFF1 and Alzheimer disease.