EGFR and non-small cell lung carcinoma: In this study, we developed an optimized secretable bi-functional molecule, EVDRL, consisting of EGFR specific VHH (EV) fused to the extracellular domain of DR ligand (DRL) via a linker sequence and an isoleucine zipper and extensively characterized its functionality in a broad spectrum of NSCLC and NSCLC-LM cell lines.