Targeting apoptotic machinery has become an attractive therapeutic approach for primary and metastatic NSCLC.12,13 Strategies that selectively trigger apoptosis in tumor cells include targeting the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors—death receptors 4 and 5 (DR4/5). The gene discussed is TNFRSF10A; the disease is neoplasm.