Targeting apoptotic machinery has become an attractive therapeutic approach for primary and metastatic NSCLC.12,13 Strategies that selectively trigger apoptosis in tumor cells include targeting the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors—death receptors 4 and 5 (DR4/5). This evidence concerns the gene TNFSF10 and non-small cell lung carcinoma.