TNFRSF10A and non-small cell lung carcinoma: Both receptors have been shown to be overexpressed at the cell membrane in NSCLC samples compared to normal lung epithelium,14 and to act synergistically with a range of chemotherapeutic drugs such as cisplatin and pemetrexed,15-18 providing a rationale for the use of DR4/5 targeted therapy in NSCLC.