Histopathological analysis on lung sections by H&E staining confirmed the presence of tumors, and IHC and immunofluorescence staining with EGFR- and DR4/5-specific antibodies depicted the upregulation of these markers in the NSCLC in vivo (Fig. 1G, 1H, 1K). Here, EGFR is linked to non-small cell lung carcinoma.