To confirm DYRK1A complementation could rescue infection with authentic virus, we challenged these cell lines with the icSARS-CoV-2-mNG reporter virus or WT SARS-CoV-2 WA/01/2020 to assess viral replication by mNG production and by plaque assay, respectively [81] (Figs 3D, 3E, and S2A). Here, DYRK1A is linked to infection.