For patients with IL-6 ≥ 416.4 pg/ml at admission and a lymphocyte count < 0.7 × 109/L on the 5th day, the SOFA score was high; the length of the hospital stay, ICU stay, and mechanical ventilation time were significantly prolonged; the 28-day mortality rate was higher; and the proportion of patients with secondary bacterial infections during the disease course was also higher, suggesting that the disease condition was more critical and the prognosis was worse. This evidence concerns the gene IL6 and bacterial infectious disease.