While the expression of IRF1 was significantly increased in PBMCs from patients with severe or critical COVID-19 (Fig. 6B), its expression in monocytes was increased only in patients with severe COVID-19 (Fig. 7B), as was observed with IL27p28 and EBI3 (Fig. 2E and F and Fig. 3E and F). The gene discussed is IRF1; the disease is COVID-19.