We did not observe changes in IFN-I (IFNα and IFNβ), IFN-II (IFNγ), or IFN-III (IFNλ1) mRNA levels in COVID-derived PBMCs or monocytes, except for IFNλ1, which was significantly increased in PBMCs from patients with critical COVID-19. This evidence concerns the gene IFNA1 and COVID-19.