The roles of nucleic acids, including miRNAs, circRNAs, and DNA fragments, in sEVs are well characterized.[15, 43, 44] For instance, in one of our previous studies, we showed that circular RNA Ube3a from M2 macrophage‐derived sEVs mediate myocardial fibrosis after acute myocardial infraction.[43] However, it is unclear whether sEV proteins are involved in cardiac remodeling. The gene discussed is UBE3A; the disease is Myocardial fibrosis.