Consistent with these mouse data, Sema3A expression was significantly higher in the hypertrophic hearts (Figure 2K and Figure S3I, Supporting Information) and plasma (Figure S3J, Supporting Information) of patients, in the serum of patients with hypertension‐related cardiac dysfunction (Figure S3L,M, Supporting Information), and in the hearts of SHRs (Figure S3H, Supporting Information) compared to the corresponding controls. Here, SEMA3A is linked to Hypertension.