SRF and Hepatic fibrosis: Corroborating recent studies, SRF has been demonstrated to be a profibrotic molecule in hypertrophic remodeling and liver fibrosis.[27, 28, 29] For instance, knockdown of SRF in hepatic stellate cells attenuated carbon tetrachloride‐induced hepatic fibrosis.[30, 31] Other studies have shown that hypoxia‐induced upregulation of SRF impairs endothelial cell function.[32] Collectively, these data support that SRF is a pathogenic mediator in fibrotic, remodeling, and hypertrophy‐associated processes in different types of cells.