PI3 and skin aging: Indicated by docking score, the results showed that alpha-pinene, camphene, cyclohexane, indole and limonene could bind with PI3 better, folinic acid, isoquercitrin and stearic acid could bine with PHGD, BCEH, CXCR2 better respectively, indicating these 8 AAK compounds may exert pharmacological effect on skin aging by targeting PI3, HGD, BCEH and CXCR2, respectively.