As reported, skin aging is involved in the process of cell proliferation, oxidative stress, apoptosis, inflammation and skin barrier repairing etc. It is reported that Alvespimycin suppressed the inflammasome/Caspase-1/GSDMD signal pathway [28], TW-37 obviously improved inflammation by inhibiting the proliferation of human oral cancer cell lines such as MC-3, HSC-3 [43, 44]. The gene discussed is GSDMD; the disease is lip and oral cavity carcinoma.