CASP3 and melanoma: Camphene had strong antioxidant effects on scavenging the activity of hydroxyl and superoxide radicals [46], SRT-1720 suppressed the ROS generation against oxidative stress [47], TTNPB significantly up-regulated the expression of caspase-3, thus induced apoptosis of human melanoma cell [48], and Stearic acid could also induce apoptosis via same pathways [49].