EZH2 and cancer: Extrapolating from findings in other cell types, several non-mutually exclusive mechanisms could be at play, including direct modification or transcriptional regulation via histone methylation of cell cycle regulators (Xu and Richard, 2021), stimulating EZH2 activity (Li et al., 2021), or regulating Myc activity, as found in cancer cells (Favia et al., 2019; Tikhanovich et al., 2017; Hsu et al., 2021).