METTL3 and psoriasis: Furthermore, Xian et al. reported that downregulating methyltransferase-like 3 (METTL3) in psoriasis stabilized lncRNA AGAP2-AS1 by reducing its m6A modification; AGAP2-AS1 then functioned as a competitive endogenous RNA (ceRNA) by sponging miR−424-5p to upregulate AKT3 and activate the AKT – mTOR pathway, hence promoting keratinocyte proliferation [47].