APOE and colorectal carcinoma: However, when APOE-overexpressing CRC cells were transfected with two siRNAs targeting LRP1, the migrated and invaded cells of si-LRP1 groups were significantly lower than those of si-NC groups, indicating that the migration- and invasion-promoting phenomenon of APOE-overexpression was significantly suppressed by LRP1 knockdown (Figure 6C and 6D).