To illuminate the molecular characteristics of apolipoproteins in CRC, we initially analyzed the expression pattern of 11 apolipoproteins (apolipoprotein A1 [APOA1], apolipoprotein A2 [APOA2], apolipoprotein A4 [APOA4], apolipoprotein A5 [APOA5], apolipoprotein B [APOB], apolipoprotein C1 [APOC1], apolipoprotein C2 [APOC2], apolipoprotein C3 [APOC3], apolipoprotein C4 [APOC4], apolipoprotein D [APOD], and APOE) in CRC patients with or without lymphatic invasion using the UCSC Xena database (Figure 1A). Here, APOE is linked to colorectal carcinoma.