CD4 and angina pectoris: Interestingly,IFNγ-producing CD8+ T cells have been shown to be persistently higher in patientswith coronary artery disease with acute coronary syndrome and stable angina,46 with human plaques showing moreactivated CD8 than CD4.47 Indeed,IL-1 induces expression of multiple CXC chemokines able to recruit CXCR3+ Tcells.48 Lesions inIL-1αTM/Apoe−/− mice also have less VSMCs and collagen andrelatively smaller fibrous caps, which are related given that VSMCs produce the collagenthat supports fibrous caps.