Interestingly,IFNγ-producing CD8+ T cells have been shown to be persistently higher in patientswith coronary artery disease with acute coronary syndrome and stable angina,46 with human plaques showing moreactivated CD8 than CD4.47 Indeed,IL-1 induces expression of multiple CXC chemokines able to recruit CXCR3+ Tcells.48 Lesions inIL-1αTM/Apoe−/− mice also have less VSMCs and collagen andrelatively smaller fibrous caps, which are related given that VSMCs produce the collagenthat supports fibrous caps. This evidence concerns the gene APOE and acute coronary syndrome.