It should be noted that concomitant use of systemic glucocorticoids with cytochrome P450 3A4 (CYP3A4) inhibitors, such as ritonavir and antifungal drugs, could decrease the metabolization of synthetic glucocorticoids, like dexamethasone and prednisolone, by CYP3A4, which could put patients at higher risk of developing adrenal insufficiency [60-64]. The gene discussed is CYP3A4; the disease is Adrenal insufficiency.