Systemic injection of GCP II inhibitor ZJ‐43 and its prodrug PGI‐02776 within the first 30 min after the injury can reduce the acute neuropathological and TBI‐related long‐term cognitive impairment caused by excessive extracellular glutamate,84 significantly reduce the harmful effect of TBI combined with secondary hypoxic injury,85 and reduce the exercise and cognitive impairment combined with TBI and the second hypoxic injury within a few weeks after injury.86 This evidence concerns the gene FOLH1 and Cognitive impairment.