Moreover, our results indicated that PPM1F mRNA dramatically decreased in the mPFC of male, but not female depressed mice (male: t(18) = 3.3300, p = 0.0037; female: t(15) = 1.6050, p = 0.1294), and PPM1F mRNA levels were positively correlated with depression‐related behaviors, percentage of sucrose preference and immobility time in male mice only (Figure 1D). The gene discussed is PPM1F; the disease is major depressive disorder.