Comorbidities with physical diseases in 28 cases include irritable bowel syndrome, allergic rhinitis, migraine, atopic dermatitis, functional dyspepsia, chronic sinusitis, obesity, ventricular septal defect, scoliosis, precocious puberty, nephropathy IgA, and Marfan syndrome. The gene discussed is CD79A; the disease is ventricular septal defect 1.