Cui and Colleagues reported, indeed, that HOTAIR levels increase in recipient laryngeal cancer cells after treatment with exosomes from another line of producing cancer cells; besides, HOTAIR levels correlate with radiosensitivity, because in the same cells this lncRNA can act as a ceRNA for miR-454-3p, thus modulating the transcription factor E2F2 expression [109]. The gene discussed is HOTAIR; the disease is laryngeal carcinoma.