The functional role of HNF4α in controlling HOTAIR expression was investigated by means of overexpression, silencing or impairment of protein activity after TGFβ-mediated treatment by using as experimental models (i) hepatocyte cells undergoing the EMT/MET [35, 39, 40], (ii) hepatocyte-specific HNF4α knockout mice [41] and (iii) colon cancer cells mimicking different states of tumor progression [42]. The gene discussed is HNF4A; the disease is malignant colon neoplasm.