Further, the associations of SKP2 expression with DNA methyltransferases (DNMTs), mismatch repair genes (MMRGs), microsatellite instability (MSI), tumor mutational burden (TMB), neoantigen count, and immunity (e.g., filtration levels of immune cells) were also revealed, which may promote understanding of SKP2 in pan-cancers. This evidence concerns the gene SKP2 and cancer.