Similarly, differential SKP2 expression was detected in different cell lines of neoplasms (p < 0.05) (Fig. 2B), and such a phenomenon was also found in tissues of 18 types of 21 investigated neoplasms — high SKP2 expression in 15 neoplasms (bladder urothelial carcinoma [BLCA], etc.)and low SKP2 expression in three neoplasms — KICH (kidney chromophobe), PRAD (prostate adenocarcinoma), and THCA (thyroid carcinoma) (p < 0.05) (Fig. 2C). Here, SKP2 is linked to thyroid gland carcinoma.