SKP2 and cancer: The CRISPR results demonstrated the essential cancer role of SKP2 in a series of neoplasms, including BLCA, CESC, COAD, ESCA, STAD, LIHC, SKCM, PRAD, SARC, THCA, UCS (uterine carcinosarcoma), and UVM (gene effect < 0) (Fig. 9C).