On the other hand, SKP2 was negatively correlated with immune microenvironment scores in some tumors (such as ACC, SKCM, TGCT, and GBM), suggesting that SKP2 may also be involved in significantly negative regulation of the immune microenvironment in these tumors and then affect the prognosis of patients. This evidence concerns the gene SKP2 and adrenal cortex carcinoma.