MSH2 and cancer: A recent study among 1,244 patients with OS (mean age at diagnosis, 16 years) indicated that 28% of patients harbored pathogenic (P) or likely pathogenic (LP) cancer susceptibility gene variants in TP53 and in genes previously not linked to OS (e.g., CDKN2A, MEN1, VHL, POT1, APC, MSH2, ATRX) [5].