Our analysis focused on the four major human alcohol metabolism genes or gene clusters, including ADH, CYP2E1, ALDH1, and ALDH2. Variants in these genes have been previously investigated for influencing ethanol metabolism or modifying the effect of alcohol on breast cancer risk, including ADH1B*2 (rs1229984), ADH1B*3 (rs2066702), ADH1C*1 (rs698), CYP2E1*5 (rs2031920-T, rs3813867-C, and rs6413432-A), CYP2E1*6 (rs6413432-A) and ALDH2*2 (rs671) [53, 57]. This evidence concerns the gene CYP2E1 and breast cancer.