ESR1 and triple-negative breast carcinoma: In the genetic main effects meta-analysis, we identified multiple testing-corrected statistically significant per-allele associations (see Additional file 1: Table S3, for locus-specific significance thresholds) between rs79865122-C in the CYP2E1 locus on chromosome 10 and odds of ER- (OR (95% CI) = 0.21 (0.12, 0.40), pSNP = 9.91 × 10–7), PR- (OR (95% CI) = 0.27 (0.15, 0.50), pSNP = 1.87 × 10–5), and triple negative breast cancer (OR (95% CI) = 0.23 (0.11, 0.48), pSNP = 1.15 × 10–4).