The multivariate logistic regression analysis showed that, after adjustments for the cardiovascular risk factors age, male sex, BMI, having been a smoker, hypertension, CAD, CVD, LDL-C, FBG, HbA1c, IL-6, CRP and OPG levels were independent determinant for MACE after LER in diabetic patients with CLTI (p < 0.01) (Table 2). The gene discussed is TNFRSF11B; the disease is Hypertension.