C4A and hepatocellular carcinoma: Furthermore, the expression of CLEC1B was associated with the immune subtypes of HCC patients, and different expression level of CLEC1B was observed among the five immune subtypes (C1: wound healing; C2: IFN-γ dominant; C3: inflammatory; C4: lymphocyte depleted; C6: TGF-β dominant), with the highest and lowest expression in C3 and C4 subtypes, respectively (Fig. 5C, D).