From the proteins we selected in SIDA and BIPnet the pathways LXR/RXR activation, FXR/RXR activation, atherosclerosis signaling, IL-12 signaling and production in macrophages, acute phase response signaling, maturity-onset diabetes of young (MODY) signaling, and neuroprotective role of THOP1 in Alzheimer’s disease were selected. Here, THOP1 is linked to type 2 diabetes mellitus.