Notable examples include a nonsense variant in TBC1D4, which confers muscle insulin resistance and increases risk for type 2 diabetes (T2D) and is common in Greenland but rare or absent in other populations [17], several common EAS-specific coding variants that influence blood lipids by exerting a protective effect against alcoholism [18, 19], and two loci associated with major depression that are more common in the Chinese population than EUR (i.e., 45% vs. 2% for rs12415800, and 28% vs. 6% for rs35936514) [20, 21]. The gene discussed is TBC1D4; the disease is type 2 diabetes mellitus.