INS and type 1 diabetes mellitus: This is in contrast to previous hypoglycaemia induction studies in type 1 diabetes, where close-to-normal doses of insulin detemir and neutral protamine Hagedorn insulin led to clinically significant hypoglycaemia in 78% of participants and triple doses of insulin degludec and glargine U100 led to clinically significant hypoglycaemia in almost all participants [8, 24].