STAT3 and glioblastoma: Subsequently, the cell viability assay was performed to verify the importance of HOXD‐AS‐STAT3 axis in TMZ sensitivity and showed that HOXD‐AS2 promoted the TMZ resistance, the IC50 value increased to 2504 μM from 806.3 μM, nevertheless, STAT3 inhibition reversely sensitized glioblastoma to temozolomide, and IC50 value decreased to 1438 μM from 2504 μM (Figure 5O), indicating the importance of HOXD‐AS2‐STAT3 axis in TMZ‐sensitivity regulation.