ACOD1 and Insulin resistance: Consistent with the patterns of expression we documented, Irg1 deficiency in the myeloid compartment was sufficient to yield elevated insulin resistance as Irg1fl/fl × LysMCre mice exhibited similar insulin intolerance as global Irg1−/− mice; regardless of whether mice were fed a control diet (Fig. 5g) or WD (Fig. 5h).