Accordingly, it should be noted that the THY-1 and LUM genes (whose expression is shown in Fig. 4c) are also targeted by JARID1B, and both genes are down-regulated in the metastatic melanoma cells overexpressing PIR. Moreover, the rates of proliferation assayed (Fig. 3c) were in agreement with this molecular analysis, since both c-MYC and E2F1 are proteins involved in cell proliferation and cell cycle regulation. Here, KDM5B is linked to metastatic melanoma.