MCAM and neoplasm: To demonstrate whether increasing the number of CD146+ macrophages would improve antitumor activity, we established a model in which tumor cells (Hepa1-6 or MC38) were mixed with a 0.5-fold number of Raw264.7 cells transfected with empty plasmid (CTR) or Cd146-plasmid (CD146-Ov) (Fig. S2G) and then subcutaneously injected into WT mice (Fig. 3H).