In DEN-induced liver cancer, although we observed no significant difference in the percentages of DCs and NK cells, more CD11b+Gr-1+ MDSCs (including M-MDSCs and G-MDSCs) and Tregs were observed in the TME (Fig. S2E, F), confirming the immunosuppressive environment in M-KO mice. This evidence concerns the gene ITGAM and liver cancer.