To assess the antitumor activity of JMT101 plus afatinib or osimertinib, common EGFR 20ins in NSCLC, A767_V769dup (insASV), S768_D770dup (insSVD) and N771_H773dup (insNPH), were stably expressed in Ba/F3 cells. Here, EGFR is linked to non-small cell lung carcinoma.