Notably, predicted interactions from keratinocytes include CCL2 and CCL7 to CCR2 in myeloid cells, CCL20 to CCR6 and IL7 to IL7R in myeloid cells and T cells, and insulin-like growth factor family ligands (IGFL1, IGFL2, IGFL3) to their receptor (IGFLR1) on T cells (Fig. 7d), suggesting that keratinocytes regulate the immune response in psoriasis. The gene discussed is IGFL1; the disease is psoriasis.