As the ex vivo IL-10 release was increased as a consequence of COVID-19 vaccinations by factor ~ 2–3 under both basal and ConA conditions, while the respective IL-6 release was increased by factor ~ 600 under basal conditions and by factor ~ 6000 under ConA conditions, these findings suggest a strong and SARS-CoV-2-unspecific proinflammatory reprogramming of the T cell compartment by COVID-19 vaccinations. This evidence concerns the gene IL10 and COVID-19.