TGM2 and hepatocellular carcinoma: Since growth suppression was not observed in a previous study of HCC cells with the ethyl analogs of ACR at the carboxyl group [22], we synthesized a novel derivative of ACR by introducing an amino group on the terminus opposite of the carboxyl group (H2N-ACR) (Fig. S1) and established an analytical strategy to examine the binding of TG2 and ACR with H2N-ACR immobilized magnetic nanobeads (FG beads) (Fig. 1A).