Of interest, in agreement with our findings regarding the role of TG2 in regulating membrane-related signaling in HCC cells, Gene Ontology (GO) annotation for “Molecular Function” and “Cellular Component” indicated that most of the TG2-correlated genes in human HCC tumors encode proteins that are in membrane and involved in protein binding function (Fig. 6B, C). The gene discussed is TGM2; the disease is hepatocellular carcinoma.