TGM2 and hepatocellular carcinoma: Similar to their suppressive effects on HCC cell proliferation, induction of TG2 oligomer formation was observed with SVK30, having an ACR-like structure, but not with the ethyl analogs of ACR [22, 81], suggesting that the binding of ACR with TG2 is likely related to the carboxylate terminus of the chain containing three isoprene residues of ACR.