We observed the increased expression of Slc1a3, the EAAT1, in 3xTg-AD mice exposed to alcohol, which appears consistent with the increased excitatory/inhibitory balance in AD patients, leading to cortical and hippocampal hyperexcitability and cognitive impairment (Palop et al., 2007; Lauterborn et al., 2021; Zhang et al., 2022). This evidence concerns the gene SLC1A3 and Alzheimer disease.