Cmss1 (Cms1 Ribosomal Small Subunit Homolog) was selectively downregulated in 3xTg-AD mice exposed to alcohol versus WT mice without alcohol exposure but not in 3xTg-AD mice and WT mice exposed to alcohol versus WT controls in multiple neuronal and non-neuronal cell types, including L5/6 nonpeptidergic (NP), L5 external tufted (ET), L2/3 IT, L5 IT, L6b, L6 corticothalamic (CT), VIP, parvalbumin, Meis2, Sncg and SSt interneurons, Lamp5, astrocytes, microglia-perivascular macrophages (PVMs), oligodendrocytes, and OPCs (Fig. 4A, Extended Data Fig. 4-1). Here, LAMP5 is linked to Alzheimer disease.