In endothelial cells, several upregulated genes in 3xTg-AD mice exposed to alcohol versus WT controls but not in 3xTg-AD mice or WT mice exposed to alcohol versus WT controls were previously found to be upregulated in aged capillaries, including innate immunity genes, such as Ly6a, Ly6c1, B2m, H2-K1, H2-D1, and Ifitm3 (Chen et al., 2020). This evidence concerns the gene LY6S and Alzheimer disease.