Deep and superficial excitatory neurons showed a broad increase in the transcription of cadherins that are upregulated in seizures and implicated in sprouting, synapse formation, and excitatory/inhibitory balance (Shan et al., 2002; Williams et al., 2011; Smith et al., 2017); therefore, they may also underlie increased excitability in the cortex in AD and a history of excessive alcohol exposure. Here, CDH17 is linked to Alzheimer disease.