CDK8 and Alzheimer disease: The cyclin-dependent kinase Cdk8 was selectively downregulated in 3xTg-AD mice exposed to alcohol versus WT controls but not in 3xTg-AD mice or WT mice exposed to alcohol versus WT controls in multiple non-neuronal cell types, including both astrocytes and microglia-PVM, VLMC (ventral laryngeal motor cortex), and oligodendrocytes, and similar trends were present in some neuronal populations.