Several ribosomal proteins were selectively decreased in 3xTg-AD mice exposed to alcohol versus WT controls but not in 3xTg-AD mice and WT mice exposed to alcohol versus WT controls in L6 IT neurons, including Rpl23a, Rpl13a, Rpl35a, Rpl36a, Rpl37, and Mrpl33 [Mrpl33 also decreased in Sst and L2/3 intratelencephalic (IT) neurons]. The gene discussed is RPL23A; the disease is Alzheimer disease.