Parvalbumin and VIP interneurons and L6 CT neurons showed the increased transcription of Glra2 (glycine receptor α2; Fig. 4A, Extended Data Fig. 4-1), and VIP interneurons showed the increased expression of Grid2 (glutamate receptor GluRδ2; Extended Data Fig. 4-1) in 3xTg-AD mice exposed to alcohol versus WT controls but not in 3xTg-AD mice versus WT controls or in WT mice exposed to alcohol versus WT controls. Here, PVALB is linked to Alzheimer disease.