Upregulated genes in endothelial cells of 3xTg-AD mice exposed to alcohol were indicative of aged capillaries, including innate immunity genes, such as Ly6a, Ly6c1, Ifitm3, B2m, H2-K1, and H2-D1 (Chen et al., 2020). The gene discussed is B2M; the disease is Alzheimer disease.