We used triple-transgenic AD (3xTg-AD) mice, which harbor three familial AD (FAD) mutations, including transgenes of the human amyloid precursor protein (APP) Swedish double mutation (KM670/671NL) and the human tauP301L mutation, and knockin of the human presenilin (PS1) M146V mutation (Oddo et al., 2003). This evidence concerns the gene APP and Alzheimer disease.