SOCS3 and liver cancer: Intrathecal treatment with lncRNAs downregulated in liver cancer stem cell (DILC) siRNA in bCCI rats alleviates mechanical allodynia and thermal hyperalgesia by promoting the suppressor of cytokine signaling 3 (SOCS3) expression and downregulating the JAK2/STAT3 pathway leading to enhanced microglial viability, reduced cell apoptosis, and inflammation [40].