SARM1 and major depressive disorder: To further confirm this observation, both TST and FST tests also showed no significant difference in the percentage of immobility time among the four groups of mice at 3-month-old (Supplementary Fig. 5E, F) and 8-month-old (Supplementary Fig. 6B-D), suggesting that the depression-like behaviors was not observed after deletion of SARM1 in CNS.