However, as shown in Figure 5, we also found that some important inflammatory cytokines, including TNF-α and NF-κB, were decreased after the deletion of SARM1 in AD model mice, which indicated that the impairment of glial activation in neuronal SARM1-deficient AD model mice is likely to be the response to inflammatory factors. The gene discussed is SARM1; the disease is Alzheimer disease.