SARM1 and Alzheimer disease: But, intriguingly, our studies showed the deletion of SARM1 in the AD model mice could alleviate Aβ deposition to some extent, thereby preventing cognitive impairment (Fig. 2 and Fig. 3), which was consistent with previous studies that have demonstrated the negative impact of SARM1 on cognitive impairment in various diseases such as traumatic brain injury and postoperative cognitive dysfunction [18].