However, no significant alteration between 3-month-old APP/PS1;SARM1f/f mice and APP/PS1;SARM1Nestin-CKO mice was observed in memory-related phenotypes, including the latency in the MWM test and the percentage of spontaneous alternations in the Y-maze experiment (Supplementary Fig. 2A-D), suggesting SARM1 deletion did not affect the cognitive in AD model mice at an early stage. Here, APP is linked to Alzheimer disease.