REN and inborn error of immunity: Combing the consistent results of relative and absolute data, 4 pathways (staurosporine biosynthesis, renin secretion, mannose type O-glycan biosynthesis and other types of O-glycan biosynthesis) at KEGG level 3 were enriched in iRBD, while 4 pathways (primary immunodeficiency, glycerophospholipid metabolism, cationic antimicrobial peptide resistance and biotin metabolism) were increased in NC (Fig. 3A).