In addition, in the PLM, anti-PDGF-BB antibodies and STI571 also inhibited LNM caused by co-injection of CAFs and CCA cells (Fig. 7D-F, S16A-C), and correspondingly, there were fewer lymphatic vessels in the pad tumors of mice with blocked PDGF-BB/PDGFR signaling (Fig. 7G-I, S13C, S16D-F). The gene discussed is PDGFRB; the disease is cholangiocarcinoma.