CXCL12 and neoplasm: CAFs secrete a variety of signaling molecules (such as interleukin 1 beta (IL-1β), platelet-derived growth factor beta homodimer (PDGF-BB) and stromal cell-derived Factor 1 (SDF1)), which promote tumor progression by enhancing proliferation, migration, invasion, chemotaxis, and intratumoral angiogenesis [9].