Conditional deletion of Mettl3 or Mettl14 in murine CD4+ T cells impairs T cell differentiation and homeostasis [70, 71], while mice lacking Mettl3 or Mettl14 specifically in Treg cells displayed severe autoimmunity despite normal numbers of Foxp3+ Treg cells [72, 73]. This evidence concerns the gene METTL3 and Autoimmunity.