Flex-sweep also identified sweep windows in TLR5 (Toll-like receptor 5) (Hawn et al. 2003; Abu-Maziad et al. 2010; Grossman et al. 2013), ITGAE (integrin subunit alpha E) (Grossman et al. 2013; Triska et al. 2015; Ravenhall et al. 2018; Harris and DeGiorgio 2020), and APOL1 (apolipoprotein L1) (Mizuno et al. 2010; Ko et al. 2013; Thomson et al. 2014), all previously identified as sweeps associated with infectious diseases or pathogen response by both genomic and functional studies. The gene discussed is TLR5; the disease is infectious disease.