[8] The phenotype of homologous protection against either infection or severity has been observed using a variety of approaches including challenge studies of a radiation-attenuated Plasmodium falciparum sporozoite vaccine [9,10] and of P. vivax used as neurosyphilis therapy,[11] as well as in field studies of monovalent vaccines targeting P. falciparum apical membrane antigen 1 (AMA-1) [12] and circumsporozoite protein (CSP). The gene discussed is DNAJC5; the disease is infection.