Onthe other hand, CD63 and CD81 are broadly expressed in both SCLC andNSCLC lines.28 To date, most studies onQCM-D and SPR lung cancer cell-derived EVs have focused mainly onCD63 detection,29−31 and the analysis of only a few tetraspanins leadsto the determination of only EVs in the analyzed solution, not theother EV-type particles. This evidence concerns the gene CD81 and lung cancer.