Considering the patient's history of malar rash, leucopenia, low C3 levels, and current wrist tenderness, it is recommended to refer this patient to a rheumatologist. These symptoms and laboratory findings could suggest an autoimmune condition such as systemic lupus erythematosus (SLE) or another connective tissue disease. A rheumatologist has the specialized knowledge and experience to evaluate, diagnose, and manage such conditions. This evidence concerns the gene C3 and connective tissue disorder.