GnRH-a downregulates the pituitary-ovarian-gonadal axis to treat adenomyosis.30,31 Estrogen deficiency restricts the long-term use of GnRH analogs for premenopausal symptoms.32 Currently, the effects of mifepristone on sex hormones remain unclear.33 We found no statistically significant differences in FSH, LH, and E2 levels between groups for the 12-week treatment. This evidence concerns the gene GNRH1 and adenomyosis.