CD274 and neoplasm: According to the previous definition [21], tumor microenvironment immune types (TMIT) were as follows: TMIT I (PD-L1 + /CD8High) = 12 samples (27.9%); TMIT II (PD-L1 − /CD8Low) = 10 samples (23.3%); TMIT III (PD-L1 + /CD8Low) = 20 samples (46.5%), and TMIT IV (PD-L1 − /CD8High) = 1 sample (2.3%) (Fig. 3D and Suplementary Table 5).