Kaplan-Meier analysis using a cohort of GC patients in the TCGA database showed that patients with CBLB mutations had shorter OS and PFS than wild-type patients (OS: P = 0.0036; PFS: P = 0.0027).<h4>Conclusions</h4>This study confirmed the utility and feasibility of ctDNA in the prognosis monitoring of gastric cancer. This evidence concerns the gene CBLB and gastric cancer.