Current progresses from genomic and proteomic studies have highlighted common pathogenic mechanisms underlying migraine and CKD involving vascular development and endothelial function (Carlsson et al. 2017; Gormley et al. 2016; Guo et al. 2020), and loci mapping to genes CPS1 (Choquet et al. 2021; Wuttke et al. 2019) and SMG6 (Hautakangas et al. 2022; Wuttke et al. 2019) are found to affect both migraine and kidney function. This evidence concerns the gene CPS1 and migraine disorder.