CD4 and esophageal squamous cell carcinoma: The proportions of immune cells in ESCC calculated by xCell algorithm are shown in Fig. 7A and B. Epithelial cells, macrophages M2, mast cells, memory B cells, B cells, CD4+ Tem cells, class-switched memory B cells, CLP, and endothelial cells showed noteworthy difference between high-risk and low-risk groups (P < 0.05).